Linguistics

Contains reports on one research project.National Institutes of Health (Grant 5 TO1 HD00111-08)National Institute of Mental Health (Grant 5 P01 MH13390-07

Linguistics

Contains research objectives and reports on four research projects.National Institutes of Health (Grant 5 TO1 HD00111-08)National Institute of Mental Health (Grant 2 P01 MH13390-06

Linguistics

Contains reports on five research projects.National Institute of Mental Health (Grant 5 PO1 MH-13390-04

Imaging and imagination: understanding the endo-lysosomal system

Lysosomes are specialized compartments for the degradation of endocytosed and intracellular material and essential regulators of cellular homeostasis. The importance of lysosomes is illustrated by the rapidly growing number of human disorders related to a defect in lysosomal functioning. Here, we review current insights in the mechanisms of lysosome biogenesis and protein sorting within the endo-lysosomal system. We present increasing evidence for the existence of parallel pathways for the delivery of newly synthesized lysosomal proteins directly from the trans-Golgi network (TGN) to the endo-lysosomal system. These pathways are either dependent or independent of mannose 6-phosphate receptors and likely involve multiple exits for lysosomal proteins from the TGN. In addition, we discuss the different endosomal intermediates and subdomains that are involved in sorting of endocytosed cargo. Throughout our review, we highlight some examples in the literature showing how imaging, especially electron microscopy, has made major contributions to our understanding of the endo-lysosomal system today

The influence of clause structure on the perceptual analysis of sentences

Thesis (Ph. D.)--Massachusetts Institute of Technology. Dept. of Foreign Literatures and Linguistics, 1974.MIT Humanities Library copy bound in 2 pts."February, 1974." Some leaves folded. Vita.Bibliography: leaves 305-310.by Judith R. Kornfeld.Ph.D

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes

Mucolipidosis II mice, as well as patients with this disorder, exhibit extensive vacuolization of their exocrine gland cells. We now demonstrate that the vacuoles are enlarged autolysosomes containing undigested cytoplasmic material that accumulate secondary to deficient lysosomal degradative function. A model to explain this finding is proposed